Compositions and methods for plasmapheresis
US-2024277911-A1 · Aug 22, 2024 · US
US8999715B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999715-B2 |
| Application number | US-201113240009-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 22, 2011 |
| Priority date | Aug 8, 2005 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
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The invention claimed is: 1. An in vitro method for obtaining a genetically modified memory T cell population that is CD4+ or CD8+, comprising the steps of: a) activating lymphocytes in vitro in a cell-free medium with at least two specific activating receptor agonist antibodies that are able to drive lymphocyte activation, wherein one of the lymphocyte activating receptor agonist antibodies is specific for CD3 polypeptide and the other lymphocyte activating receptor agonist antib…
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