Use of common γ chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes

US8999715B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8999715-B2
Application numberUS-201113240009-A
CountryUS
Kind codeB2
Filing dateSep 22, 2011
Priority dateAug 8, 2005
Publication dateApr 7, 2015
Grant dateApr 7, 2015

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Abstract

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It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.

First claim

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The invention claimed is: 1. An in vitro method for obtaining a genetically modified memory T cell population that is CD4+ or CD8+, comprising the steps of: a) activating lymphocytes in vitro in a cell-free medium with at least two specific activating receptor agonist antibodies that are able to drive lymphocyte activation, wherein one of the lymphocyte activating receptor agonist antibodies is specific for CD3 polypeptide and the other lymphocyte activating receptor agonist antib…

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What does patent US8999715B2 cover?
It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
Who is the assignee on this patent?
Bonini Maria Chiara, Bondanza Attilio, Ospedale San Raffaele Srl
What technology area does this patent fall under?
Primary CPC classification G01N33/56972. Mapped technology areas include Physics.
When was this patent published?
Publication date Tue Apr 07 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).