Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
US-2015368676-A1 · Dec 24, 2015 · US
US8999700B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999700-B2 |
| Application number | US-201313926054-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 25, 2013 |
| Priority date | Nov 20, 2000 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.
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We claim: 1. A transformed yeast or bacterial cell for producing 3-hydroxypropionic acid (3-HP), wherein the transformed cell comprises a metabolic pathway that produces: acetyl-CoA from pyruvate, malonyl CoA from the acetyl-CoA, and 3-HP from the malonyl CoA, wherein the transformed cell comprises at least one exogenous nucleic acid molecule that does not naturally occur in the transformed cell and encodes acetyl-CoA carboxylase, a polypeptide that reduces malonyl-CoA, or c…
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