Detection of nucleic acids using a cantilever sensor

Patent metadata

Field	Value
Publication number	US-8999640-B2
Application number	US-201313955408-A
Country	US
Kind code	B2
Filing date	Jul 31, 2013
Priority date	Feb 16, 2007
Publication date	Apr 7, 2015
Grant date	Apr 7, 2015

Abstract

Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe material is known to bind to the target nucleic acid. The prepared sensor is exposed to the target nucleic acid. The target nucleic acid binds to the probe material. The mass accumulated on the sensor reflects the amount of target nucleic acid bound to the probe material.

First claim

What is claimed:

1. A method comprising:
exposing a sensor to a medium, the sensor comprising:
a piezoelectric layer comprising a proximate end and a distal end;
a base portion coupled to the proximate end of the piezoelectric layer;
a non-piezoelectric layer, wherein:
at least a portion of the piezoelectric layer is coupled to at least a portion of the non-piezoelectric layer such that one of:
the distal end of the piezoelectric layer extends beyond an end of the non-piezo…

Assignees

• Mutharasan Rajakkannu
• Rijal Kishan
• Maraldo David R
• Campbell Gossett Augustus
• Univ Drexel

Inventors

• Mutharasan Rajakkannu
• Rijal Kishan
• Maraldo David R
• Campbell Gossett Augustus

Classifications

• G01N33/54373 Primary

  Physics · mapped topic

• G01N2291/0427

  Physics · mapped topic

• C12Q1/6825 Primary

  Chemistry & Metallurgy · mapped topic