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Modified polynucleotides for the production of biologics and proteins associated with human disease
US8999380B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999380-B2 |
| Application number | US-201313791922-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 9, 2013 |
| Priority date | Apr 2, 2012 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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Abstract
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The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
First claim
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We claim: 1. An isolated polynucleotide comprising; (a) a first region of linked nucleosides, said first region encoding a polypeptide of interest, said polypeptide of interest is SEQ ID NO: 1089; (b) a first flanking region located at the 5′ terminus of said first region comprising at least one 5′ terminal cap; (c) a second flanking region located at the 3′ terminus of said first region comprising a 3′ tailing sequence of linked nucleosides; and wherein at least one…
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Frequently asked questions
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- What does patent US8999380B2 cover?
- The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
- Who is the assignee on this patent?
- modeRNA Therapeutics, Moderna Therapeutics Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N15/85. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 07 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).