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Immunoconjugates with an intracellularly-cleavable linkage
US8999344B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999344-B2 |
| Application number | US-201414294651-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 3, 2014 |
| Priority date | Feb 13, 2009 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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Abstract
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The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
First claim
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We claim: 1. A method for treating cancer comprising administering to a subject with cancer, wherein the cancer is a hematopoietic tumor, a sarcoma, a melanoma or a glial tumor, an immunoconjugate having a structural formula of MAb- CL2A-SN-38, with a structure represented by: 2. The method of claim 1 , wherein the conjugate is administered in combination wit…
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Frequently asked questions
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- What does patent US8999344B2 cover?
- The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
- Who is the assignee on this patent?
- Immunomedics Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K16/1145. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 07 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).