Crispr/cas-related methods and compositions for knocking out c5
US-2024415980-A1 · Dec 19, 2024 · US
Immunobinders directed against sclerostin
US8999331B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999331-B2 |
| Application number | US-201213659647-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 24, 2012 |
| Priority date | Oct 24, 2011 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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Abstract
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Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.
First claim
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What is claimed is: 1. A binding protein comprising an antigen binding domain capable of binding human sclerostin, the antigen binding domain comprising three CDRs in a heavy chain and three CDRs in a light chain, wherein the heavy chain comprises a CDR-H1, a CDR-H2 and a CDR-H3; wherein the CDR-H1 comprises the amino acid sequence of X 1 -L-S-X 2 -H (residues 31-35 of SEQ ID NO: 1); wherein X 1 is E or G; and wherein X 2 is M, V or L; wherein the CDR-H2 comprises the a…
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- What does patent US8999331B2 cover?
- Proteins that bind sclerostin or sclerostin and TNF are described along with there use in composition and methods for treating, preventing, and diagnosing sclerostin related diseases and for detecting sclerostin or sclerostin and TNF in cells, tissues, samples, and compositions.
- Who is the assignee on this patent?
- Hsieh Chung-Ming, Ivanov Alexander, Waegell Wendy, and 8 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/18. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 07 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).