System and method for intraparenchymal drug infusion

Patent metadata

Field	Value
Publication number	US-8998885-B2
Application number	US-88173210-A
Country	US
Kind code	B2
Filing date	Sep 14, 2010
Priority date	Oct 24, 2006
Publication date	Apr 7, 2015
Grant date	Apr 7, 2015

Abstract

A system for performing an intraparenchymal drug infusion including a pump device, a delivery tube, a sensor, and a processor. The tube is fluidly coupled to the pump device, establishing an infusate pathway from the pump to an infusate exit port of the delivery tube. The sensor is positioned to sense a parameter indicative of pressure in the infusate pathway. Finally, the processor is programmed to generate information indicative of infusate delivery effectiveness of a drug infusion procedure based upon information from the sensor. In some embodiments, the processor generates a net infusion pressure profile, such as a pressure-time curve, and prompts display of the pressure profile to a neurosurgeon for subsequent evaluation of infusate delivery effectiveness.

First claim

What is claimed is:

1. A system for use with an intraparenchymal drug infusion procedure in which a drug is delivered from a source to an intracerebral target site via an infusate pathway, the system comprising:
a sensor positioned to sense a parameter indicative of pressure in the infusate pathway;
a display device; and
a processor programmed to:
generate a pressure profile for a current intraparenchymal drug infusion procedure infusing drug through the infusate pathway to the intracerebral target site based upon information from the sensor,
generate comparative information relating to the current intraparenchymal drug infusion procedure,
prompt the display device to simultaneously display the pressure profile and the comparative information, the simultaneous display being indicative of infusate delivery effectiveness of the current intraparenchymal drug infusion procedure, including indicative of whether a therapeutically effective volume of distribution of the infusate remains at the intracerebral target site.

2. The system of claim 1 , further comprising a conduit fluidly forming a sensor pathway that connects the sensor to the infusate pathway.

3. The system of claim 2 , wherein the conduit branches from a delivery tube otherwise defining the infusate pathway such that the sensor pathway is fluidly in-line with the infusate pathway.

4. The system of claim 1 , further comprising a conduit fluidly connected to the sensor and terminating in a sensor exit port, wherein the sensor exit port is located in close proximity to an exit port of the infusate pathway.

5. The system of claim 4 , wherein the conduit is connected to a delivery tube otherwise defining the infusate pathway.

6. The system of claim 1 , wherein the processor is programmed to generate the pressure profile on a real-time basis.

7. The system of claim 1 , wherein the pressure profile is a pressure-time curve.

8. The system of claim 1 , wherein the processor is programmed to prompt the display device to display the pressure profile in graph form.

9. The system of claim 1 , wherein the processor is programmed to determine baseline pressure information of an intended target site of the current intraparenchymal drug infusion procedure, the comparative information including the baseline pressure information.

10. The system of claim 9 , wherein the baseline pressure information is based upon information from the sensor, and is a sum of an interstitial fluid pressure and a hydrostatic pressure difference between a height of the sensor and a height of the infusate exit port.

11. The system of claim 9 , wherein the processor is programmed to determine baseline pressure information on a real-time basis.

12. The system of claim 9 , wherein the processor is further programmed to formulate a net infusion pressure profile as a function of fluid pressure, as indicated by the sensor, and the baseline pressure information.

13. The system of claim 1 , wherein the system further includes a memory storing a library of reference pressure profiles in graphical form.

14. The system of claim 13 , wherein the processor is further programmed to select a reference pressure profile from the library, the comparative information including the selected reference pressure profile.

15. The system of claim 14 , wherein the processor is programmed to prompt the display device to simultaneously display the pressure profile and the selected reference pressure profile.

16. The system of claim 14 , wherein the processor is programmed to select the reference pressure profile from the library based upon user-entered information relating to a type of the drug being delivered with the current intraparenchymal drug infusion procedure and an intended infusion site of the current intraparenchymal drug infusion procedure.

17. The system of claim 16 , wherein the user-entered information relating to an intended infusion site includes a designation of white matter or gray matter.

18. The system of claim 1 , wherein the pressure profile is indicative of infused tissue type.

19. The system of claim 1 , wherein the pressure profile is indicative of infusate leakage.

20. The system of claim 1 , further comprising:
a pump device for delivering the drug from a source located outside of the patient; and
a delivery tube fluidly coupled to the pump for delivering drug from the pump to an infusate exit port of the tube;
wherein the pump and the tube combine to define an infusate pathway to the infusate exit port.

21. The system of claim 20 , wherein the pump device is adapted to produce a constant flow of the pumped drug.

22. The system of claim 20 , wherein the system is adapted to perform an intracerebral drug infusion procedure.

Assignees

• Nelson Brian D
• Gronda Ann M
• Adams Matthew H
• Medtronic Inc

Inventors

• Nelson Brian D
• Gronda Ann M
• Adams Matthew H

Classifications

• A61M5/16854

  by monitoring line pressure · CPC title

• A61M2210/0693

  Brain, cerebrum · CPC title

• A61M2205/52

  with memories providing a history of measured variating parameters of apparatus or patient · CPC title

• A61M5/1452 Primary

  pressurised by means of pistons · CPC title

• A61M5/14276

  specially adapted for implantation · CPC title