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US-2015347817-A1 · Dec 3, 2015 · US
System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue
US8995740B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8995740-B2 |
| Application number | US-201313865036-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 17, 2013 |
| Priority date | Apr 17, 2013 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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Improved systems and methods for the analysis of digital images are provided. More particularly, the present disclosure provides for improved systems and methods for the analysis of digital images of biological tissue samples. Exemplary embodiments provide for: i) segmenting, ii) grouping, and iii) quantifying molecular protein profiles of individual cells in terms of sub cellular compartments (nuclei, membrane, and cytoplasm). The systems and methods of the present disclosure advantageously perform tissue segmentation at the sub-cellular level to facilitate analyzing, grouping and quantifying protein expression profiles of tissue in tissue sections globally and/or locally. Performing local-global tissue analysis and protein quantification advantageously enables correlation of spatial and molecular configuration of cells with molecular information of different types of cancer.
First claim
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The invention claimed is: 1. A computer-implemented method for performing multi-channel hierarchical image segmentation analysis of tissue types, cell units and sub-cellular units in biological tissue, the method comprising: accessing image data corresponding to multi-channel multiplexed image of biological tissue sequentially fluorescent stained to manifest expression levels of a plurality of morphological biomarkers in the biological tissue; performing multi-channel image segm…
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- G06K9/0014Primary
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
- G06T7/0012Primary
Physics · mapped topic
- G06V20/695Primary
Physics · mapped topic
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- What does patent US8995740B2 cover?
- Improved systems and methods for the analysis of digital images are provided. More particularly, the present disclosure provides for improved systems and methods for the analysis of digital images of biological tissue samples. Exemplary embodiments provide for: i) segmenting, ii) grouping, and iii) quantifying molecular protein profiles of individual cells in terms of sub cellular compartments …
- Who is the assignee on this patent?
- Gen Electric
- What technology area does this patent fall under?
- Primary CPC classification G06K9/0014. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).