Microscopy system and method for creating three dimensional images using probe molecules

US8994807B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8994807-B2
Application numberUS-201013257588-A
CountryUS
Kind codeB2
Filing dateMar 18, 2010
Priority dateMar 18, 2009
Publication dateMar 31, 2015
Grant dateMar 31, 2015

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Abstract

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A system ( 100 ) and method for creating three dimensional images using probe molecules is disclosed and described. A sample is mounted on a stage ( 160 ). The sample has a plurality of probe molecules. The sample is illuminated with light, causing the probe molecules to luminesce. The probe luminescence can be split into at least four paths corresponding to at least four detection planes corresponding to object planes in the sample. The at least four detection planes are detected via a camera ( 155 ). Object planes in corresponding recorded regions of interest are recorded in the camera ( 155 ). A signal from the regions of interest is combined into a three dimensional image.

First claim

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What is claimed is: 1. A microscopy system for creating three dimensional images using probe molecules, comprising: a sample stage for mounting a sample, said sample containing the probe molecules; an optional activation light source configured to illuminate the sample with an activation light and to activate probe molecules in at least one subset of the probe molecules; a readout light source configured to illuminate the sample with a readout light and to cause luminescence i…

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What does patent US8994807B2 cover?
A system ( 100 ) and method for creating three dimensional images using probe molecules is disclosed and described. A sample is mounted on a stage ( 160 ). The sample has a plurality of probe molecules. The sample is illuminated with light, causing the probe molecules to luminesce. The probe luminescence can be split into at least four paths corresponding to at least four detection planes corre…
Who is the assignee on this patent?
Bennett Brian Thomas, Bewersdorf Joerg, Jorgensen Erik, and 6 more
What technology area does this patent fall under?
Primary CPC classification G02B21/367. Mapped technology areas include Physics.
When was this patent published?
Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).