Compositions and methods for accurately identifying mutations
US-2024409996-A1 · Dec 12, 2024 · US
US8994076B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8994076-B2 |
| Application number | US-201213607428-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 7, 2012 |
| Priority date | May 29, 2009 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
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What is claimed is: 1. A chemically-sensitive field effect transistor (chemFET), comprising: a substrate including a semiconductor well, wherein the semiconductor well has a conductivity type opposite that of the substrate; a gate dielectric on the semiconductor well; a floating gate structure disposed over the gate dielectric; a passivation layer over the floating gate structure; a first diode connected between the floating gate structure and the semiconductor well, where…
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