Genetically modified porcine cells, tissue, and animals with reduced human xenoreactivity and methods of using the same
US-2024271103-A1 · Aug 15, 2024 · US
Model of Alzheimer's Disease
US8993833B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993833-B2 |
| Application number | US-22861108-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 14, 2008 |
| Priority date | Aug 14, 2007 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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A modified non-human warm-blooded vertebrate animal in which a biologically active human APP polypeptide is expressed, and in which function of its inducible Nitric Oxide Synthase (iNOS) protein is reduced as compared to a non-modified animal, methods of making the animal, and methods of testing a candidate composition for activity in the treatment of Alzheimer's Disease using the animal.
First claim
Opening claim text (preview).
What is claimed is: 1. A modified mouse comprising both: (i) a transgene encoding a biologically active human Amyloid Peptide Precursor (APP) polypeptide comprising a Swedish familial K670N/M671L double mutation (APPsw), wherein the transgene encoding the biologically active human APP polypeptide comprising a Swedish familial K670N/M671L double mutation (APPsw) is integrated into the genome of the modified mouse under control of a promoter sequence; and (ii) a knockout or knockd…
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Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- A01K67/0275Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US8993833B2 cover?
- A modified non-human warm-blooded vertebrate animal in which a biologically active human APP polypeptide is expressed, and in which function of its inducible Nitric Oxide Synthase (iNOS) protein is reduced as compared to a non-modified animal, methods of making the animal, and methods of testing a candidate composition for activity in the treatment of Alzheimer's Disease using the animal.
- Who is the assignee on this patent?
- Colton Carol Anne, Vitek Michael Peter, Davis Judianne, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A01K67/0275. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).