Cyclic compounds
US-9828357-B2 · Nov 28, 2017 · US
Process for preparing zanamivir and intermediates for use in the process
US8993789B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993789-B2 |
| Application number | US-200913130692-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 24, 2009 |
| Priority date | Nov 28, 2008 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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The present invention provides a process for preparing methyl 5-acetamido-4-amino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminum hydride, sodium borohydride, zinc/ammonium chloride, zinc-ferric chloride and ferric chloride/sodium iodide. The present invention also provides compounds of formula (VIII) and (IX) which may be used in the synthesis of zanamivir. The present invention also provides processes for preparing compounds (VIII) and (IX) and processes involving their use, including in the synthesis of zanamivir.
First claim
Opening claim text (preview).
The invention claimed is: 1. Methyl 5-acetamido-4-cyanamido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate of formula (VIII) 2. Methyl 5-acetamido-4-cyanamido-6-(1,2,3-trihydroxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate of formula (IX)…
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- C07D309/28Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8993789B2 cover?
- The present invention provides a process for preparing methyl 5-acetamido-4-amino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminum hydride, sodium borohydride, z…
- Who is the assignee on this patent?
- Phull Manjinder Singh, Kankan Rajendra Narayanrao, Rao Dharmaraj Ramachandra, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07D309/28. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).