Anti-cancer compound and pharmaceutical composition containing the same
US-9221817-B2 · Dec 29, 2015 · US
Positive allosteric modulators of MGLUR2
US8993779B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993779-B2 |
| Application number | US-201113814870-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 5, 2011 |
| Priority date | Aug 12, 2010 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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- Title
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Abstract
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The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved, such as schizophrenia.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound according Formula Ic or a pharmaceutically acceptable salt thereof, wherein E 1 and E 2 are independently C or N; ring B is phenyl or heteroaryl, R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and each R 6 is independently selected from the group consisting of: CN, halo, R 5 , —O—R 5 , —N(R)—R 5 , —…
Assignees
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Classifications
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07D235/26Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8993779B2 cover?
- The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and t…
- Who is the assignee on this patent?
- Dudkin Vadim Y, Fraley Mark E, Arrington Kenneth L, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification C07D235/26. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).