Lymph directing prodrugs
US-2024050573-A1 · Feb 15, 2024 · US
Use of oripavine as a starting material for buprenorphine
US8993764B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993764-B2 |
| Application number | US-15902506-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 18, 2006 |
| Priority date | Jan 5, 2006 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.
First claim
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The invention claimed is: 1. A method for producing norbuprenorphine, the method comprising: a) reacting oripavine according to Formula I with methyl vinyl ketone to form a compound according to Formula II; b) hydrogenating the compound according to Formula II to form a compound according to Formula III;…
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Chemistry & Metallurgy · mapped topic
- C07D489/12Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8993764B2 cover?
- There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demet…
- Who is the assignee on this patent?
- Mannino Anthony, Hoefgin Erik R, Hill Lloyd P, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07D489/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).