Nucleic acid-controlled catalytic rnas for trigger-responsive regulation
US-2024425855-A1 · Dec 26, 2024 · US
Nuclease resistant double-stranded ribonucleic acid
US8993746B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993746-B2 |
| Application number | US-201213431376-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 27, 2012 |
| Priority date | May 27, 2004 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
First claim
Opening claim text (preview).
We claim: 1. A method of increasing the nuclease resistance of a dsRNA, comprising the steps of: (a) identifying in the nucleotide sequences of the antisense strand of an unmodified dsRNA all occurrences of the dinucleotides 5′-ua-3′, 5′-ca-3′, 5′-ug-3′, 5′-uu-3′, 5′-cc-3′, 5′-uc-3′ and 5′-cu-3′; and (b) replacing the 5′-uridines and/or 5′-cytidines in all occurrences of at least one of the dinucleotides identified in (a) with 2′-modified uridines and/or cytidines, respectively;…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C12N15/111Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8993746B2 cover?
- This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
- Who is the assignee on this patent?
- Vornlocher Hans-Peter, Roehl Ingo, Hadwiger Philipp, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification C12N15/111. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).