Compositions and methods for targeted delivery to cells
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SMNdelta7 degron: novel compositions and methods of use
US8993741B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993741-B2 |
| Application number | US-201013510149-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 17, 2010 |
| Priority date | Nov 17, 2009 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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The present invention includes an isolated nucleic acid comprising a nucleic acid sequence encoding a SMNΔ7 degron and the encoded polypeptide. The invention also includes inhibitors of SMNΔ7 degron. The invention also includes compositions and methods for mitigating SMN deficiency by targeting inhibition of factors that mediate SMNΔ7-degron dependent degradation of SMNΔ7.
First claim
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What is claimed: 1. An isolated nucleic acid encoding a chimeric polypeptide comprising a degradation signal sequence and a target sequence, wherein the degradation signal sequence consists of SEQ ID NO. 3 or SEQ ID NO. 14. 2. An isolated nucleic acid consisting of SEQ ID NO. 3 or SEQ ID NO. 14, wherein said nucleic acid is operably linked to sequence of a vector.
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- What does patent US8993741B2 cover?
- The present invention includes an isolated nucleic acid comprising a nucleic acid sequence encoding a SMNΔ7 degron and the encoded polypeptide. The invention also includes inhibitors of SMNΔ7 degron. The invention also includes compositions and methods for mitigating SMN deficiency by targeting inhibition of factors that mediate SMNΔ7-degron dependent degradation of SMNΔ7.
- Who is the assignee on this patent?
- Dreyfuss Gideon, Cho Sungchan, Univ Pennsylvania
- What technology area does this patent fall under?
- Primary CPC classification C07K14/47. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).