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Notch-based fusion proteins and uses thereof
US8993725B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993725-B2 |
| Application number | US-65757310-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 21, 2010 |
| Priority date | Apr 29, 2004 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
First claim
Opening claim text (preview).
What is claimed is: 1. A fusion protein consisting of consecutive amino acids, the amino acid sequence of which, commencing at the amino terminus, is identical to the amino acid sequence of EGF repeats 1-29 of human Notch4, followed by a linker sequence of amino acids which is followed by an amino acid sequence identical to the sequence of an Fc portion of an antibody, wherein the amino acid sequence of EGF repeats 1-29 of human Notch4 is encoded by the nucleic acid coding sequence…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8993725B2 cover?
- This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising …
- Who is the assignee on this patent?
- Kitajewski Jan, Shawber Carrie, Funahashi Yasuhiro, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K48/00. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).