Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Patent metadata

Field	Value
Publication number	US-8993590-B2
Application number	US-201414205885-A
Country	US
Kind code	B2
Filing date	Mar 12, 2014
Priority date	Mar 14, 2013
Publication date	Mar 31, 2015
Grant date	Mar 31, 2015

Abstract

The present invention discloses compounds according to Formula I:

Wherein R 1a , R 1b , R 2 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , W, X, Cy, and the subscript a are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.

First claim

The invention claimed is:

1. A compound according to Formula I:

wherein
R 1a is H, halo or C 1-4 alkyl;
R 1b is:
halo,
C 1-4 alkyl (which alkyl is optionally substituted with one or more independently selected halo), or
C 1-4 alkoxy (which alkoxy is optionally substituted with one or more independently selected halo);

X is —S—, —O—, —N═…

Assignees

• Galapagos Nv

Inventors

• Desroy Nicolas
• Heckmann Bertrand
• Brys Reginald Christophe Xavier
• Joncour Agnès Marie
• Peixoto Christophe
• Bock Xavier Marie

Classifications

• A61P35/00

  Human Necessities · mapped topic

• A61P3/10

  Human Necessities · mapped topic

• A61P37/00

  Human Necessities · mapped topic

• A61P9/10

  Human Necessities · mapped topic

• A61P35/02

  Human Necessities · mapped topic