Inhibitors of tyk2
US-2024425484-A1 · Dec 26, 2024 · US
US8993585B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993585-B2 |
| Application number | US-17544108-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 17, 2008 |
| Priority date | Jul 17, 2007 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.
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We claim: 1. A compound of formula I: N-oxide, or therapeutically acceptable salt thereof; wherein: X is selected from alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, aminocarbonyl, carboxyl, carboxyl ester, cyano, fluoro, chloro, nitro, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, and trihalomethyl; R 1…
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