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Processes for preparing JAK inhibitors and related intermediate compounds
US8993582B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993582-B2 |
| Application number | US-201313761830-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 7, 2013 |
| Priority date | Jan 15, 2009 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
First claim
Opening claim text (preview).
What is claimed is: 1. A process of preparing a composition comprising an enantiomeric excess of the (R)-enantiomer of a compound of Formula III′: comprising: reacting said compound of Formula I″: with boron trifluoride diethyl etherate, followed by aqueous ammo…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07D487/04Primary
Chemistry & Metallurgy · mapped topic
- C07D231/16Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8993582B2 cover?
- The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and …
- Who is the assignee on this patent?
- Zhou Jiacheng, Meloni David, Liu Pingli, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07D487/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).