Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines derivatives and [1,4]oxazino[2,3,4-hi]pyrido[4,3-b]indole derivatives

Patent metadata

Field	Value
Publication number	US-8993572-B2
Application number	US-201113642652-A
Country	US
Kind code	B2
Filing date	Apr 22, 2011
Priority date	Apr 22, 2010
Publication date	Mar 31, 2015
Grant date	Mar 31, 2015

Abstract

The invention relates to particular substituted heterocycle fused gamma-carbolines of formula I:

as described herein, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT 2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D2 receptor signaling systems.

First claim

The invention claimed is:

1. A compound of Formula I:

wherein:
X is —N(H)— or —N(CH 3 )— and Y is —C(H)(OH)—;

in solid free base or salt form.

2. A compound of Formula I

wherein:
X is —N(H)— or —N(CH 3 )— and Y is —C(H)(OH)—;
in…

Assignees

• Mates Sharon
• Davis Robert
• Wennogle Lawrence P
• Li Peng
• Tomesch John Charles
• Zhang Qiang
• Intra Cellular Therapies Inc

Inventors

• Mates Sharon
• Davis Robert
• Wennogle Lawrence P
• Li Peng
• Tomesch John Charles
• Zhang Qiang

Classifications

• A61P5/06

  Human Necessities · mapped topic

• A61P25/24

  Human Necessities · mapped topic

• A61P25/18

  Human Necessities · mapped topic

• A61P25/20

  Human Necessities · mapped topic

• A61P25/22

  Human Necessities · mapped topic