Pyridazinedione-based heterobicyclic covalent linkers and methods and applications thereof
US-2024425465-A1 · Dec 26, 2024 · US
US8993570B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993570-B2 |
| Application number | US-201313959716-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 5, 2013 |
| Priority date | Jun 23, 2009 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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This invention relates to novel substituted triazolo-pyridazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an α1-GABA A receptor antagonist or an α2- and/or an α3-GABA A receptor partial agonist.
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What is claimed is: 1. A method of treating a subject suffering from, or susceptible to, a disease or condition selected from anxiety, convulsions, and neuropathic pain, comprising the step of administering to the subject in need thereof an effective amount of a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is —CH 3 , or —CH 2 CH 3 ,…
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