(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors

US8993565B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8993565-B2
Application numberUS-201414312124-A
CountryUS
Kind codeB2
Filing dateJun 23, 2014
Priority dateJul 2, 2009
Publication dateMar 31, 2015
Grant dateMar 31, 2015

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  2. Abstract

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  5. First independent claim

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Abstract

Official abstract text for this publication.

The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.

First claim

Opening claim text (preview).

The invention claimed is: 1. A method of treating cancer capable of being modulated by inhibition of AKT phosphorylation in a patient in need thereof comprising administering to said patient an effective dose of a compound according to formula (I): in which: R1 represents an aryl or heteroaryl radical optionally substituted with one or more substituents, which may be…

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What does patent US8993565B2 cover?
The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.
Who is the assignee on this patent?
Sanofi Sa
What technology area does this patent fall under?
Primary CPC classification C07D413/06. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).