Process for preparing [(3-hydroxypyridine-2-carbonyl)amino]alkanoic acids, esters and amides
US-2015361043-A1 · Dec 17, 2015 · US
US8993557B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993557-B2 |
| Application number | US-201214347683-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 26, 2012 |
| Priority date | Sep 30, 2011 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
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What is claimed is: 1. A compound of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein: R 1 is selected from the group consisting of: H, C 1-6 alkyl substituted with 0-3 R a , C 2-6 alkenyl substituted with 0-3 R a , and —(CH 2 ) n —W—(CH 2 ) m —R 1a ; W is selected from the group consisting of: a bond, NH, O, S, N(C…
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