Natural combination hormone replacement formulations and therapies

Patent metadata

Field	Value
Publication number	US-8993549-B2
Application number	US-201414475864-A
Country	US
Kind code	B2
Filing date	Sep 3, 2014
Priority date	Nov 23, 2011
Publication date	Mar 31, 2015
Grant date	Mar 31, 2015

Abstract

Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.

First claim

What is claimed is:

1. A pharmaceutical composition comprising:
solubilized estradiol;
suspended progesterone; and
a solubilizing agent;
wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed;
wherein at least about 90% of the estradiol is solubilized in the solubilizing agent; and
wherein the solubilizing agent comprises an effective amount of a monoglyceride, a diglyc…

Assignees

• Therapeuticsmd Inc

Inventors

• Bernick Brian A
• Cacace Janice Louise
• Persicaner Peter H R
• Irani Neda
• Amadio Julia M

Classifications

• A61P43/00

  Human Necessities · mapped topic

• A61K47/10

  Human Necessities · mapped topic

• A61K9/4858

  Human Necessities · mapped topic

• A61K47/14

  Human Necessities · mapped topic

• A61K9/48

  Human Necessities · mapped topic