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3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses
US8993547B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993547-B2 |
| Application number | US-201213495548-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 13, 2012 |
| Priority date | Jun 14, 2011 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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This invention discloses 3-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D 3 and (20R)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D 3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to monocytes thus evidencing use as anti-cancer agents especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also exhibit relatively high calcemic activity evidencing use in the treatment of bone diseases.
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We claim: 1. A compound of the formula: where X is selected from the group consisting of hydrogen and a hydroxy-protecting group, and where R is hydrogen, an alkyl, hydroxyalkyl or fluoroalkyl group, or R is a side chain of the formula: where the stereochemical cent…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
- C07F9/5325Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8993547B2 cover?
- This invention discloses 3-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D 3 and (20R)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D 3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells…
- Who is the assignee on this patent?
- Deluca Hector F, Plum Lori A, Sicinski Rafal R, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07F9/5325. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).