Compositions and methods for inhibition of the jak pathway
US-2017158683-A1 · Jun 8, 2017 · US
Diphenyl sulfide derivative and pharmaceutical product which contains same as active ingredient
US8993543B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993543-B2 |
| Application number | US-201113883847-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 20, 2011 |
| Priority date | Dec 21, 2010 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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[Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity. [Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.
First claim
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The invention claimed is: 1. A diphenyl sulfide derivative, or a pharmaceutically acceptable salt or hydrate thereof, represented by an (S)-2-amino-4-{2-chloro-4-(5-ethoxy-2-hydroxyphenylthio)phenyl}-2-propylbutylphosphoric acid monoester. 2. A medicine, comprising the diphenyl sulfide derivative according to claim 1 , or a pharmaceutically acceptable salt or hydrate thereof. 3. The medicine according to claim 2 , wherein the medicine is…
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- What does patent US8993543B2 cover?
- [Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity. [Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an…
- Who is the assignee on this patent?
- Ishikawa Kumi, Koga Shigeru, Kohno Yasushi, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07F9/38. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).