Oligomeric compounds comprising tricyclic nucelosides and methods for their use

Patent metadata

Field	Value
Publication number	US-8993528-B2
Application number	US-201313848623-A
Country	US
Kind code	B2
Filing date	Mar 21, 2013
Priority date	Mar 21, 2008
Publication date	Mar 31, 2015
Grant date	Mar 31, 2015

Abstract

The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

First claim

What is claimed is:

1. An oligomeric compound comprising at least one tricyclic nucleoside having formula II:

wherein independently for each of said tricyclic nucleosides having formula II:
Bx is a heterocyclic base moiety;
one of T 1 and T 2 is an internucleoside linking group attaching said tricyclic nucleoside of formula II to said oligomeric compound and the othe…

Assignees

• Isis Pharmaceuticals Inc

Inventors

• Swayze Eric E
• Siwkowski Andrew M
• Seth Punit P
• Prakash Thazha P

Classifications

• A61K31/7042

  Human Necessities · mapped topic

• A61K31/7088

  Human Necessities · mapped topic

• C12N2310/3231

  Chemistry & Metallurgy · mapped topic

• C12N2310/316

  Chemistry & Metallurgy · mapped topic

• A61K31/7052

  Human Necessities · mapped topic