A novel acylated insulin analog
US-2024374692-A1 · Nov 14, 2024 · US
Meal-time insulin analogues of enhanced stability
US8993516B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993516-B2 |
| Application number | US-93761209-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 14, 2009 |
| Priority date | Apr 14, 2008 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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A method treating a patient includes administering a physiologically effective amount of a fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof to the patient. The fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof, contains an insulin A-chain sequence modified at position A8 and an insulin B-chain sequence or an analogue thereof. The fibrillation-resistant insulin analogue may exhibit thermodynamic stability similar to or exceeding that of wild-type human insulin and displays a susceptibility to fibrillation similar to or exceeding that of wild-type human insulin. An insulin analogue may display greater in vitro insulin receptor binding than normal insulin while displaying binding to IGFR less than twice that of normal insulin and less than that of fast-acting insulin analogs. The fibrillation-resistant insulin may be used to treat a patient by subcutaneous injection or by using an implantable or external insulin pump, due to its fibrillation resistance.
First claim
Opening claim text (preview).
I claim: 1. A composition comprising a vertebrate insulin analogue or a physiologically acceptable salt thereof, containing a first substitution at position A8, wherein the first substitution is a tryptophan substitution or a methionine substitution, and also containing at least one second substitution that provides a decreased lag time for activity compared to a corresponding wild-type vertebrate insulin, wherein the at least one second substitution comprises an aspartic acid subs…
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Frequently asked questions
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- What does patent US8993516B2 cover?
- A method treating a patient includes administering a physiologically effective amount of a fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof to the patient. The fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof, contains an insulin A-chain sequence modified at position A8 and an insulin B-chain sequence or an analogue thereof…
- Who is the assignee on this patent?
- Weiss Michael, Univ Case Western Reserve
- What technology area does this patent fall under?
- Primary CPC classification C07K14/62. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).