Methods and Compositions for Generating Bioactive Assemblies of Increased Complexity and Uses
US-2015374846-A1 · Dec 31, 2015 · US
US8993349B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993349-B2 |
| Application number | US-90595010-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 15, 2010 |
| Priority date | Oct 6, 2000 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. Kits comprising reagents for performing such methods are also provided.
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What is claimed is: 1. A composition, comprising a micelle dispersed in aqueous solution, wherein the micelle comprises: (a) one or more semiconductor nanoparticles encapsulated with a negatively charged amphiphilic polymer, wherein the amphiphilic polymer is a block copolymer or grafted polymer that comprises at least one hydrophilic segment and at least one hydrophobic segment that encapsulates the one or more semiconductor nanoparticles through hydrophobic interaction, and (b…
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