Method for tagging material with surface-enhanced spectroscopy (SES)-active composite nanoparticles
US-9201013-B2 · Dec 1, 2015 · US
Method of producing functional molecule-containing silica nanoparticles on which biomolecules are bonded
US8993345B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993345-B2 |
| Application number | US-201314063666-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 25, 2013 |
| Priority date | Apr 26, 2011 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof to coexist with a linker molecule having a maleimido group and a carboxyl group in an aprotic solvent, thereby allowing formation of a thioether bond between the thiol group and the maleimido group, and obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded to coexist with carbodiimide and a biomolecule having an amino group in an aqueous solvent, thereby allowing formation of an amide bond between the carboxyl group active esterified by the carbodiimide, and the amino group of the biomolecule.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, comprising the steps of: mixing organoalkoxysilane having a functional molecule and tetraalkoxysilane in an ammonia-containing aqueous solvent to allow formation of silica core particles containing the functional molecule in the solvent, thereby obtaining a dispersion liquid of the core particles; and adding organoalkoxysilane having a thiol gr…
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Physics · mapped topic
- G01N33/54346Primary
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US8993345B2 cover?
- A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof to coexist with a linker molecule having a maleimido group and a carboxyl group in an aprotic solvent, thereby allowing formation of a thioether b…
- Who is the assignee on this patent?
- Furukawa Electric Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification G01N33/54346. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).