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Methods for detection and analysis of polynucleotide-binding protein interactions
US8993335B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993335-B2 |
| Application number | US-77941204-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 13, 2004 |
| Priority date | Feb 13, 2003 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PBP that can bind to the target polynucleotide. The sensor PBP comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of assaying a sample for the presence of a target polynucleotide that binds to a polynucleotide binding protein selected from the group consisting of Tat, matrix protein M1, and hnRNP U, the method comprising: (a) contacting the sample with: (i) a sensor polynucleotide binding protein (sensor PBP) that comprises a polynucleotide binding protein selected from the group consisting of Tat, matrix protein M1, and hnRNP U linked to a signaling chromopho…
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- C12Q1/6818Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Cross-Sectional Technologies · mapped topic
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Frequently asked questions
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- What does patent US8993335B2 cover?
- Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PBP that can bind to the target polynucleotide. The sensor PBP comprises a signaling chromophore to absorb energy from the excited multichromophore and emit ligh…
- Who is the assignee on this patent?
- Bazan Guillermo C, Wang Shu, Liu Bin, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/6818. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).