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Method of efficiently establishing induced pluripotent stem cells
US8993329B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993329-B2 |
| Application number | US-201013393158-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 22, 2010 |
| Priority date | Sep 24, 2009 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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Provided are a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B to a somatic cell, particularly to a somatic cell on which Lin28 is ineffective or less effective than Lin28B in improving iPS cell establishment efficiency, and a method of producing an iPS cell, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B and a nuclear reprogramming substance to a somatic cell. Also provided are an iPS cell comprising a nucleic acid that encodes Lin28B, that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate into a somatic cell.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of improving induced pluripotent stem (iPS) cell establishment efficiency, comprising transferring Lin28B or a nucleic acid that encodes Lin28B to a somatic cell undergoing nuclear reprogramming, wherein the nuclear reprogramming is brought about by contacting the somatic cells with nuclear reprogramming substances comprising (a) Oct3/4 or a nucleic acid that encodes Oct3/4, (b) Sox2 or a nucleic acid that encodes Sox2, and (c) Klf4 or a nuclei…
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- C12N5/0696Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8993329B2 cover?
- Provided are a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B to a somatic cell, particularly to a somatic cell on which Lin28 is ineffective or less effective than Lin28B in improving iPS cell establishment efficiency, and a method of producing an iPS cell, comprising the step of transferring Lin28B or a n…
- Who is the assignee on this patent?
- Yamanaka Shinya, Tanabe Koji, Univ Kyoto
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0696. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).