Microlens array for enhanced imaging of multiregion targets
US-2015370061-A1 · Dec 24, 2015 · US
High multiplex arrays and systems
US8993307B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993307-B2 |
| Application number | US-201213552497-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 18, 2012 |
| Priority date | Sep 30, 2008 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
First claim
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We claim: 1. An array for optical analysis comprising: a transparent substrate having an upper surface comprising an array of at least 10,000 features comprising truncated cones having tops with diameters between about 0.5 microns and about 5 microns extending above the surface of the substrate, each feature having a top and sides, wherein the sides of the features comprise a reflective coating, wherein, on top of the transparent layer, and extending between the features, is a pla…
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Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US8993307B2 cover?
- Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions…
- Who is the assignee on this patent?
- Zaccarin Denis, Lundquist Paul, Zhao Peiqian, and 8 more
- What technology area does this patent fall under?
- Primary CPC classification G01N21/6452. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).