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Organisms for the production of isopropanol, n-butanol, and isobutanol
US8993285B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993285-B2 |
| Application number | US-77209410-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 30, 2010 |
| Priority date | Apr 30, 2009 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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A non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. The pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an acetone reductase. A non-naturally occurring microbial organism having an n-butanol pathway includes at least one exogenous nucleic acid encoding an n-butanol pathway enzyme. Other non-naturally occurring microbial organism have n-butanol or isobutanol pathways. The organisms are cultured to produce isopropanol, n-butanol, or isobutanol.
First claim
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What is claimed is: 1. A non-naturally occurring microbial organism having an isopropanol pathway, wherein said microbial organism comprises exogenous nucleic acids encoding each of the following isopropanol pathway enzymes: (i) a 4-hydroxybutyryl-CoA dehydratase, a crotonase, or a 3-hydroxybutyryl-CoA dehydrogenase, (ii) an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, or an acetoacetyl-CoA hydrolase, (iii) an acetoacetate decarboxylase, and (iv) a…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8993285B2 cover?
- A non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. The pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, …
- Who is the assignee on this patent?
- Burgard Anthony P, Genomatica Inc
- What technology area does this patent fall under?
- Primary CPC classification C12P17/16. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).