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Chimeric enzymes with improved cellulase activities
US8993276B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993276-B2 |
| Application number | US-201313940936-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 12, 2013 |
| Priority date | Jul 13, 2012 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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Nucleic acid molecules encoding chimeric cellulase polypeptides that exhibit improved cellulase activities are disclosed herein. The chimeric cellulase polypeptides encoded by these nucleic acids and methods to produce the cellulases are also described, along with methods of using chimeric cellulases for the conversion of cellulose to sugars such as glucose.
First claim
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We claim: 1. An isolated nucleic acid molecule encoding a chimeric CbhA polypeptide comprising domains from Clostridium thermocellum cellobiohydrolase A (CbhA) and Caldicellulosiruptor bescii cellobiohydrolase A (CelA) polypeptides, wherein the chimeric CbhA polypeptide has an amino acid sequence at least 95% identical to “SEQ ID NO:6,” and wherein the chimeric CbhA polypeptide has a cellulase activity at least 1.5-fold greater than the wild-type CbhA polypeptide.…
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- C12N9/2437Primary
Chemistry & Metallurgy · mapped topic
- C12P19/14Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8993276B2 cover?
- Nucleic acid molecules encoding chimeric cellulase polypeptides that exhibit improved cellulase activities are disclosed herein. The chimeric cellulase polypeptides encoded by these nucleic acids and methods to produce the cellulases are also described, along with methods of using chimeric cellulases for the conversion of cellulose to sugars such as glucose.
- Who is the assignee on this patent?
- Alliance Sustainable Energy
- What technology area does this patent fall under?
- Primary CPC classification C12N9/2437. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).