Non-human animals having a humanized programmed cell death 1 gene
US-2015366174-A1 · Dec 24, 2015 · US
Screening for compounds having immunosuppressant activity by testing impact on leukocyte-specific calcium fluxes
US8993244B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8993244-B2 |
| Application number | US-92222609-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 12, 2009 |
| Priority date | Mar 14, 2008 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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The invention relates to an assay for the identification of a compound having immunosuppressant activity, wherein a candidate compound is analyzed whether it blocks the Ca 2+ flux in coronin 1 expressing cells and/or in coronin 1 negative cells. A candidate compound is identified as having immunosuppressant activity if it blocks the Ca 2+ flux specifically in coronin 1 expressing cells. Further described are upstream assays wherein the impact of a candidate compound on coronin 1 trimerization is measured, and downstream assays wherein the impact of a candidate compound on diacyl glycerol (DAG) generation, phosphatidylinositol-4,5-biphosphate (PIP 2 ) levels and/or inositol-1,4,5-triphosphate (InsP 3 ) generation or on nuclear factor of activated T cells (NFAT) nuclear localization is determined.
First claim
Opening claim text (preview).
The invention claimed is: 1. An assay for identifying a compound suppressing coronin 1 trimerization, comprising: tagging peptides that are either (i) coronin 1 monomers or (ii) peptides comprising a peptide of SEQ ID NO: 5, with either fluorescence resonance energy transfer (FRET) acceptor or donor fluorescent tags resulting in tagged peptides carrying an acceptor tag and tagged peptides carrying a donor tag, or with yellow fluorescent protein (YFP) fragments resulting in tag…
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Physics · mapped topic
- G01N33/5038Primary
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
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Frequently asked questions
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- What does patent US8993244B2 cover?
- The invention relates to an assay for the identification of a compound having immunosuppressant activity, wherein a candidate compound is analyzed whether it blocks the Ca 2+ flux in coronin 1 expressing cells and/or in coronin 1 negative cells. A candidate compound is identified as having immunosuppressant activity if it blocks the Ca 2+ flux specifically in coronin 1 expressing cells. Furth…
- Who is the assignee on this patent?
- Pieters Jean, Jayac Han Dran Rajesh, Mueller Philipp, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5038. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).