Multicomponent degradable cationic polymers

US8992991B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8992991-B2
Application numberUS-201013320621-A
CountryUS
Kind codeB2
Filing dateMay 17, 2010
Priority dateMay 15, 2009
Publication dateMar 31, 2015
Grant dateMar 31, 2015

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Abstract

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Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.

First claim

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That which is claimed: 1. A compound of Formula (I): wherein: each m is independently an integer selected from the group consisting of 3, 4, 5, 6, and 8; n is an integer from 1 to 10,000; R′ is a side chain comprising a functional group selected from the group consisting of —OH, —NH 2 and —SH; and R″ is selected from the group consisting of:…

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What does patent US8992991B2 cover?
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAM…
Who is the assignee on this patent?
Green Jordan J, Sunshine Joel C, Bhise Nupura S, and 3 more
What technology area does this patent fall under?
Primary CPC classification A61K9/1075. Mapped technology areas include Human Necessities.
When was this patent published?
Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).