Synthetic peptide, and cosmetic composition or pharmaceutical composition and application thereof
US-2024352069-A1 · Oct 24, 2024 · US
US8992991B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8992991-B2 |
| Application number | US-201013320621-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 17, 2010 |
| Priority date | May 15, 2009 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
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That which is claimed: 1. A compound of Formula (I): wherein: each m is independently an integer selected from the group consisting of 3, 4, 5, 6, and 8; n is an integer from 1 to 10,000; R′ is a side chain comprising a functional group selected from the group consisting of —OH, —NH 2 and —SH; and R″ is selected from the group consisting of:…
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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