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Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds
US8992945B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8992945-B2 |
| Application number | US-67549808-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 20, 2008 |
| Priority date | Aug 27, 2007 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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A bio-adhesive supramacromolecular complex of the general formula: wherein R 1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R 2 is independently selected from the group consisting of C1-6 alkyl; R 3 and R 4 are independently selected from the group consisting of optionally substituted aliphatic or aromatic alkyl; R 5 is independently selected from the group consisting of H or C1-6 alkyl; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide linkage; R is an independently selected peptide linking group; T 1 , T 2 , T 3 and T 4 are independently selected polymer residues; and m 1 , m 2 , m 3 , n 1 and n 2 are integers selected from at least 25; and wherein P has a molecular weight of about 1×10 3 to 1×10 7 and Q has a molecular weight of about 1×10 3 to 1×10 7 . The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems. Novel compositions, methods of preparation, apparatus including layer-by-layer assemblies coating, electrospinning and ultrasonic atomization, skin coverings containing and medical use of the complexes are described.
First claim
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The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1. A bio-adhesive supramacromolecular complex of the general formula: wherein R 1 is independently selected from the group consisting of alkanes unsubstituted or substituted with alkoxy groups; R 2 is independently selected from C1-6 alkyl; R 3 and R 4 are indepen…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US8992945B2 cover?
- A bio-adhesive supramacromolecular complex of the general formula: wherein R 1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R 2 is independently selected from the group consisting of C1-6 alkyl; R 3 and R 4 are independently selected from the group consisting of optionally substituted aliphatic o…
- Who is the assignee on this patent?
- Lee Ping I, Li Yan, Univ Toronto
- What technology area does this patent fall under?
- Primary CPC classification A61K31/785. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).