Glyconjugate Vaccines
US-2024382585-A1 · Nov 21, 2024 · US
Disulfide trap MHC class I molecules and uses therefor
US8992937B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8992937-B2 |
| Application number | US-84649107-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 28, 2007 |
| Priority date | Aug 28, 2006 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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A disulfide trap, comprising an antigen peptide covalently attached to an MHC class I heavy chain molecule by a disulfide bond extending between two cysteines, is disclosed. In some configurations, a disulfide trap, such as a disulfide trap single chain trimer (dtSCT), can comprise a single contiguous polypeptide chain. Upon synthesis in a cell, a disulfide trap oxidizes properly in the ER, and can be recognized by T cells. In some configurations, a peptide moiety of a disulfide trap is not displaced by high-affinity competitor peptides, even if the peptide binds the heavy chain relatively weakly. In various configurations, a disulfide trap can be used for vaccination, to elicit CD8 T cells, and in multivalent MHC/peptide reagents for the enumeration and tracking of T cells. Also disclosed are nucleic acids comprising a sequence encoding a disulfide trap. Such nucleic acids, which can be DNA vectors, can be used as vaccines.
First claim
Opening claim text (preview).
What is claimed is: 1. A disulfide trap comprising, in amino terminal-to-carboxy terminal order, an MHC class I ligand peptide, a first linker, said first linker comprising a first cysteine, a β2-microglobulin, a second linker, and an MHC class I heavy chain sequence comprising a second cysteine, wherein said second cysteine is a substitution of an amino acid of the MHC class I heavy chain selected from the group consisting of T80C, Y84C and N86C, and wherein the first cysteine and…
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Classifications
Human Necessities · mapped topic
- A61K39/385Primary
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8992937B2 cover?
- A disulfide trap, comprising an antigen peptide covalently attached to an MHC class I heavy chain molecule by a disulfide bond extending between two cysteines, is disclosed. In some configurations, a disulfide trap, such as a disulfide trap single chain trimer (dtSCT), can comprise a single contiguous polypeptide chain. Upon synthesis in a cell, a disulfide trap oxidizes properly in the ER, and…
- Who is the assignee on this patent?
- Hansen Ted H, Fremont Daved, Connolly Janet, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/385. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).