Mutant fragments of ospa and methods and uses relating thereto
US-2016333056-A1 · Nov 17, 2016 · US
Altered OspA of Borrelia burgdorferi
US8992936B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8992936-B2 |
| Application number | US-201313944078-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 17, 2013 |
| Priority date | Aug 18, 2000 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
First claim
Opening claim text (preview).
What is claimed is: 1. A purified polypeptide, comprising inclusive and sequentially residue 139 to residue 273 of SEQ ID NO: 7 which is a Borrelia burgdorferi OspA protein except that the purified polypeptide has one to three alterations providing increased conformational stability compared to the corresponding unaltered polypeptide, wherein the one to three alterations are selected from the group consisting of the residue 139 being methionine, the residue 160 being tyrosine, th…
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Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Cross-Sectional Technologies · mapped topic
- C07K14/20Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8992936B2 cover?
- Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced…
- Who is the assignee on this patent?
- Brookhaven Sciences Ass Llc, Univ Rochester, Univ New York State Res Found
- What technology area does this patent fall under?
- Primary CPC classification C07K14/20. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).