Compositions and methods for immunooncology
US-2024417722-A1 · Dec 19, 2024 · US
Reactivation of axon growth and recovery in chronic spinal cord injury
US8992918B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8992918-B2 |
| Application number | US-92237009-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 13, 2009 |
| Priority date | Mar 13, 2008 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Abstract
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Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, and polynucleotides. Also disclosed are methods of noninvasively monitoring axonal growth during and after treatment with an axonal growth promoting agent.
First claim
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It is claimed that: 1. A method of treating chronic spinal cord injury in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of a Nogo-receptor antagonist, wherein treatment with said Nogo-receptor antagonist is initiated about twelve weeks after the spinal cord injury and wherein the administering is by chronic infusion or implantation of a controlled-release system. 2. The method of claim 1 , wherein said Nogo-…
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Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US8992918B2 cover?
- Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, and polynucleotides. Also disclosed are methods of noninvasively monitoring axonal gro…
- Who is the assignee on this patent?
- Strittmatter Stephen M, Univ Yale
- What technology area does this patent fall under?
- Primary CPC classification A61K38/177. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 31 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).