Cyclic peptide analogues for non-invasive imaging of pancreatic beta-cells

Patent metadata

Field	Value
Publication number	US-8992886-B2
Application number	US-201013263320-A
Country	US
Kind code	B2
Filing date	Apr 6, 2010
Priority date	Apr 6, 2009
Publication date	Mar 31, 2015
Grant date	Mar 31, 2015

Abstract

Compositions, methods of using and methods of making a cyclic peptide analog imaging agent that includes at least portions of a peptide or protein that binds specifically to the GLP-1 receptor (GLP-1R) and the cyclic analog has one or more conformational restrictions including, but not limited to, lactam bridges, disulfide bridges, hydrocarbon bridges, and their combinations, salts and derivatives thereof wherein the cyclic analog is more stable than a non-cyclic analog when incubated in the presence of enzymes that degrade GLP-1 and have an increased serum half-live, wherein the cyclic analog comprises at least a portion of a GLP-1 peptide or at least a portion of an Exendin peptide salts, derivatives or combinations thereof.

First claim

What is claimed is:

1. An imaging agent comprising:
a bicyclic peptide analogue corresponding to a portion of a GLP-1 peptide that binds specifically to a GLP-1 receptor (GLP-1R), wherein the bicyclic analogue has two lactam bridges, and salts thereof, and wherein the bicyclic analogue is more stable than a non-cyclic analogue when incubated in the presence of enzymes that degrade GLP-1 and has an increased serum half-life;
a linker molecule connected to the portion of a peptide…

Assignees

• Ahn Jung-Mo
• Sun Xiankai
• Univ Texas

Inventors

• Ahn Jung-Mo
• Sun Xiankai

Classifications

• A61P3/10

  Human Necessities · mapped topic

• A61K51/088 Primary

  Human Necessities · mapped topic