Engineered microorganisms for detection of diseased cells
US-2024118283-A1 · Apr 11, 2024 · US
US8992444B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8992444-B2 |
| Application number | US-72790910-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 19, 2010 |
| Priority date | Apr 29, 2005 |
| Publication date | Mar 31, 2015 |
| Grant date | Mar 31, 2015 |
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Devices, systems, and methods for determining isometric and isotonic activity of luminal organs. In an exemplary method for detecting a luminal organ response to mechanical stimulation of the present disclosure, the method comprises the steps of maintaining a luminal organ at a first internal pressure, increasing the first internal pressure of the luminal organ, and measuring a first organ parameter change in response to the increase in internal pressure. In an exemplary system for detecting a luminal organ response to mechanical stimulation of the present disclosure, the system comprises a first conduit having a proximal end, a distal end, and a lumen therethrough, the distal end sized and shaped to fit within a luminal organ, a pressure transducer, and at least one pressurized vessel capable of introducing a fluid into the lumen of the first conduit, wherein the first conduit, the pressure transducer, and the at least one pressurized vessel are either directly or indirectly coupled to one another so that a pressure of a fluid present within the first conduit can be measured using the pressure transducer.
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We claim: 1. A system for detecting a luminal organ response to mechanical stimulation, the system comprising: a first conduit and a second conduit each having a proximal end, a distal end, and a lumen therethrough, the distal ends each sized and shaped to fit within a luminal organ and configured to maintain the luminal organ at a first length within a chamber for receiving a fluid and the luminal organ; a pressure transducer in communication with at least one of the first cond…
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