Methods of synthesizing factor Xa inhibitors

US8987463B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8987463-B2
Application numberUS-201313757483-A
CountryUS
Kind codeB2
Filing dateFeb 1, 2013
Priority dateDec 17, 2009
Publication dateMar 24, 2015
Grant dateMar 24, 2015

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.

First claim

Opening claim text (preview).

What is claimed is: 1. A composition comprising at least 99.7% betrixaban free base or at least 99.7% betrixaban maleate salt. 2. The composition of claim 1 , comprising at least 99.8% betrixaban maleate salt. 3. The composition of claim 2 , comprising at least 99.9% betrixaban maleate salt. 4. A composition comprising betrixaban free base or salt thereof that comprises less than 0.15% of Compound L and/or Compound M:…

Assignees

Inventors

Classifications

  • C07D213/75Primary

    Chemistry & Metallurgy · mapped topic

  • Human Necessities · mapped topic

  • Human Necessities · mapped topic

  • Human Necessities · mapped topic

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What does patent US8987463B2 cover?
Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.
Who is the assignee on this patent?
Millennium Pharm Inc, Portola Pharm Inc
What technology area does this patent fall under?
Primary CPC classification C07D213/75. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Mar 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).