Difluorocarbene radiosynthesis
US-2024383827-A1 · Nov 21, 2024 · US
US8987463B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8987463-B2 |
| Application number | US-201313757483-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 1, 2013 |
| Priority date | Dec 17, 2009 |
| Publication date | Mar 24, 2015 |
| Grant date | Mar 24, 2015 |
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Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.
Opening claim text (preview).
What is claimed is: 1. A composition comprising at least 99.7% betrixaban free base or at least 99.7% betrixaban maleate salt. 2. The composition of claim 1 , comprising at least 99.8% betrixaban maleate salt. 3. The composition of claim 2 , comprising at least 99.9% betrixaban maleate salt. 4. A composition comprising betrixaban free base or salt thereof that comprises less than 0.15% of Compound L and/or Compound M:…
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