Process for the preparation of donepezil hydrochloride

US8987458B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8987458-B2
Application numberUS-93424509-A
CountryUS
Kind codeB2
Filing dateMar 24, 2009
Priority dateMar 25, 2008
Publication dateMar 24, 2015
Grant dateMar 24, 2015

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  1. Title

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  2. Abstract

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  5. First independent claim

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Abstract

Official abstract text for this publication.

The present invention provides a process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methylene]pyridonium halide of formula II, wherein X is bromide or chloride, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting the donepezil to the salt thereof.

First claim

Opening claim text (preview).

The invention claimed is: 1. A process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methylene]pyridonium halide of formula II wherein X − is chloride or bromide, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting donepezil to…

Assignees

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Classifications

  • Human Necessities · mapped topic

  • Chemistry & Metallurgy · mapped topic

  • C07D213/20Primary

    Chemistry & Metallurgy · mapped topic

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What does patent US8987458B2 cover?
The present invention provides a process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methylene]pyridonium halide of formula II, wherein X is bromide or chloride, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting the donepezil to the salt ther…
Who is the assignee on this patent?
Rao Dharmaraj Ramachandra, Kankan Rajendra Narayanrao, Pathi Srinivas Laxminarayan, and 1 more
What technology area does this patent fall under?
Primary CPC classification C07D213/20. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Mar 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).