Modulators of atp-binding cassette transporters
US-2016318931-A1 · Nov 3, 2016 · US
US8987458B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8987458-B2 |
| Application number | US-93424509-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 24, 2009 |
| Priority date | Mar 25, 2008 |
| Publication date | Mar 24, 2015 |
| Grant date | Mar 24, 2015 |
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The present invention provides a process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methylene]pyridonium halide of formula II, wherein X is bromide or chloride, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting the donepezil to the salt thereof.
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The invention claimed is: 1. A process for preparing donepezil or a salt thereof, the process comprising reducing a 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methylene]pyridonium halide of formula II wherein X − is chloride or bromide, in the presence of an ionic compound, a solvent, a catalyst and a source of hydrogen, to form donepezil and optionally converting donepezil to…
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