Inhibitors of tyk2
US-2024425484-A1 · Dec 26, 2024 · US
Substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C
US8987249B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8987249-B2 |
| Application number | US-201414205861-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 12, 2014 |
| Priority date | Mar 14, 2013 |
| Publication date | Mar 24, 2015 |
| Grant date | Mar 24, 2015 |
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Abstract
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This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
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We claim: 1. A compound of formula 1 wherein R 1 is independently selected from H, C 1-6 -alkyl-, halogen, HO—, C 1-6 -alkyl-O—, H 2 N—, C 1-6 -alkyl-HN—, (C 1-6 -alkyl) 2 N— and C 1-6 -alkyl-C(O)HN—; or two R 1 are together C 1-4 -alkylene; R 2 is selected from…
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- What does patent US8987249B2 cover?
- This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
- Who is the assignee on this patent?
- Anderskewitz Ralf, Binder Florian, Grauert Matthias, and 7 more
- What technology area does this patent fall under?
- Primary CPC classification C07D403/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).