Parathyroid hormone, insulin, and related peptides conjugated to bone targeting moieties and methods and making and using thereof
US-9718868-B2 · Aug 1, 2017 · US
Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8987201B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8987201-B2 |
| Application number | US-200913514362-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 7, 2009 |
| Priority date | Dec 7, 2009 |
| Publication date | Mar 24, 2015 |
| Grant date | Mar 24, 2015 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of increasing cAMP levels in a bone-forming cell comprising administering 0.10 μg/kg per day to 40 μg/kg per day of a polypeptide comprising SEQ ID NO: 2 to a human subject in need thereof. 2. A method of reducing apoptosis in a bone-forming cell comprising administering 0.10 μg/kg per day to 40 μg/kg per day of a polypeptide comprising SEQ ID NO: 2 to a human subject in need thereof. 3. A method of decreasing…
Assignees
Inventors
Classifications
Human Necessities · mapped topic
- C07K14/635Primary
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Patent family
Related publications grouped by family.
External sources
Next steps
Free tools are coming soon. Tell us what you want to track and we'll notify you.
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US8987201B2 cover?
- Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a b…
- Who is the assignee on this patent?
- Donahue Seth W, Univ Michigan Tech
- What technology area does this patent fall under?
- Primary CPC classification C07K14/635. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).