Compositions, systems, and methods for epigenetic regulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) gene expression
US-12098399-B2 · Sep 24, 2024 · US
Potent and selective mediators of cholesterol efflux
US8987192B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8987192-B2 |
| Application number | US-51911607-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 13, 2007 |
| Priority date | May 8, 2002 |
| Publication date | Mar 24, 2015 |
| Grant date | Mar 24, 2015 |
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Abstract
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The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
First claim
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What is claimed is: 1. An isolated polypeptide having cholesterol efflux and ABCA1 stabilizing activity, wherein the peptide comprises an amphipathic α-helix segment X 1 X 2 X 3 X 4 X 5 X 6 X 7 X 8 X 9 X 10 X 11 X 12 X 13 X 14 X 15 X 16 X 17 X 18 X 19 X 20 X 21 X 22 X 23 X 24 having…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- C07K14/775Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US8987192B2 cover?
- The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthe…
- Who is the assignee on this patent?
- Bielicki John K, Johansson Jan, Univ California
- What technology area does this patent fall under?
- Primary CPC classification C07K14/775. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 24 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).