Vaccine composition for use against influenza
US-9220767-B2 · Dec 29, 2015 · US
US8986987B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8986987-B2 |
| Application number | US-201113879822-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 17, 2011 |
| Priority date | Oct 18, 2010 |
| Publication date | Mar 24, 2015 |
| Grant date | Mar 24, 2015 |
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The present application applies to the field of veterinary vaccines, in particular of vaccines for poultry against avian influenza. The vaccine is based on a recombinant viral vector expressing the haemagglutinin protein of an influenza virus, wherein the vector is herpes virus of turkeys (HVT) and the haemagglutinin gene is driven by a glycoprotein B gene promoter from a mammalian herpesvirus. A vaccine comprising this HVT+HA vector can be used to induce a protective immune response against avian influenza in poultry, and to reduce the spread of AIV. The invention also relates to methods, uses, and vaccines involving the HVT+HA vector.
Opening claim text (preview).
The invention claimed is: 1. A recombinant herpes virus of turkeys (HVT) vector comprising a heterologous nucleic acid, wherein said heterologous nucleic acid comprises an extended mammalian herpesvirus glycoprotein B (gB) gene promoter operably linked to a nucleotide sequence which encodes an influenza virus (IV) hemagglutinin (HA) protein, wherein the extended mammalian herpesvirus gB gene promoter comprises the nucleotide sequence as in SEQ ID NO: 2. 2. The r…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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